Abstract
Novobiocin (NB) reduced lysis and prevented spheroplast formation in penicillin-treated E. coli. It caused a slow lysis of preformed spheroplasts when these were suspended in an environment conducive to their growth, and prevented reversion of spheroplasts to rods. It did not lyse “resting” protoplasts of Bacillus megaterium, but inhibited the growth of protoplasts, and brought about slow lysis of these forms.
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