Abstract
Acetaldehyde has no positive inotropic or chronotropic effects on hearts from guinea‐pigs pretreated with reserpine. Hearts from reserpine pretreated animals do not respond to acetaldehyde after replenishing with noradrenaline (NA) and thus made sensitive to tyramine. In hearts from reserpine pretreated animals and refilled with NA, acetaldehyde inhibits the response to tyramine in a dose‐dependent manner. The positive inotropic and chronotropic effect of acetaldehyde on normal hearts is potentiated by cocaine. Acetaldehyde by repeated administration provokes tachyphylaxis in hearts of disulfiram pretreated animals but not in normal hearts.
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