Abstract
ABSTRACT In two cases undergoing surgical sterilization and interruption of pregnancy, tritium-labelled corticosterone sulphate was injected into the intact foeto-placental circulation at laparotomy and the metabolites recovered from the placenta and various foetal tissues were analyzed. Little hydrolysis of the injected corticosterone sulphate occurred in the placenta and in the various foetal tissues, the bulk of the administered tracer being metabolized in the form of 21-sulphate. No radioactive material was detected in the glucuronide fraction. After enzymic hydrolysis of the ester-sulphate fraction, the following compounds were isolated: 21-hydroxy-pregn-4-ene-3,11,20-trione (placenta, residual foetal tissues), 3α,11β,21-trihydroxy-5β-pregnan-20-one (liver, gastrointestinal tract and placenta), 3β,11β,21-trihydroxy-5α-pregnan-20-one (liver), and 6β,11β,21-trihydroxypregn-4-ene-3,20-dione (liver, residual foetal tissues and placenta). A concept is presented describing the metabolism of corticosterone sulphate in the human foeto-placental unit at midpregnancy.
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