Abstract
1. The fate of [14C]-2-naphthylacetic acid has been studied in rat, ferret and rabbit and the findings compared with those for the 1-isomer.2. 2-Naphthylacetic acid was conjugated in all three species with glycine, glutamine, taurine and glucuronic acid.3. In rat, but not rabbit, 2-naphthylacetic acid is eliminated in the bile (50% dose) and undergoes entergohepatic circulation.4. The pattern of metabolism and elimination of 2-naphthylacetic acid in rat is dose-dependent. Small doses (5 mg/kg) are excreted in urine and bile mainly as the glucuronic acid conjugate, while larger doses (250 mg/kg) are eliminated in the bile mainly as amino acid conjugates.5. Metabolic conjugation of 1- and 2-naphthylacetic acids differs in the three species studied. 1-Naphthylacetic acid is conjugated largely with glucuronic acid and amino acid conjugation is minimal, whereas the converse is true of the 2-isomer. These differences in conjugation have been correlated with structural differences between the two acids.6. 2-Naphthylacetic acid is the first carboxylic acid found to undergo simultaneous amino acid conjugation with glycine, glutamine and taurine in non-primate species. 2-Naphthylacetic acid may be a useful probe for exploring the species occurrence of the various conjugations.
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