Abstract
SummaryIndapamide given acutely by mouth, in sub-threshold, threshold and maximal diuretic doses, did not modify plasma glucose in freely fed mice. Diazoxide, on the other hand, produced an intense dose-dependent hyperglycaemic response. In fasted mice, diazoxide, in a dose which produced little or no effect on plasma glucose, produced a marked augmentation of the hyperglycaemia produced by oral or intravenous glucose. In contrast, indapamide had no effect on the hyperglycaemia produced by orally or intravenously injected glucose, indicating a lack of effect on glucose tolerance. In anaesthetized rats, indapamide did not modify the hyperinsulinaemia produced by glucose infusion although this increase in immunoreactive insulin was completely prevented by diazoxide. The significance of these findings is discussed.
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