Abstract
Assays of melanotropic and adrenocorticotropic activities were performed on Amberlite CG-50 extracts of plasma obtained from 3 patients with untreated Addison's disease, 9 patients who had developed hyperpigmentation following bilateral adrenalectomy for Cushing's syndrome, and 1 patient who had developed hyperpigmentation and Cushing's syndrome in association with a carcinoma of the pancreas. In addition, glacial acetic acid extracts of 3 human pituitary glands and of 15 tumors associated with the “ectopic adrenocorticotropin syndrome” were similarly studied. In every instance the quantity of melanotropic activity was far greater than one would expect if the sole melanotropic substance of plasma were αh-ACTH. Furthermore, using SE-Sephadex, it was possible to separate the major melanotropic component from the major adrenocorticotropin of plasma. This separate melanotropic component of plasma was chemically different from another melanotropin which appeared in the plasma following the intravenous infusion...
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