Studies on the Mechanisms of the Monofluoroacetanilides Poisoning to Mammals

Abstract

The effects of the fluoroacetanilidase inhibitors on the fluoroaceto p-bromoanilide (FBA) poisoning to mammals and insects were studied. Triphenyl phosphate (TPP) and tri-n-butyl phosphorothioate (TBT) were mainly used as the inhibitors. 1) In the case of the oral and cutaneous toxicities to mice and rats, TPP was effective to reduce the toxicities of FBA only when applied previously to FBA. 2) In the cases of the inhaled toxicity to mice and the combined inhaled-cutaneous toxicity to mice and rats, the effects of TPP and TBT were clearly found even when applied simultaneously to FBA. 3) When TPP or TBT was administered to mice by the combined inhaled-cutaneous application, the fluoroacetanilidase activities in the liver and kidney were rapidly decreased, but recovered within 4 to 6 days after the_??_plication. 4) The insecticidal activities of FBA to use fly, Comstock mealybug, two-spotted ider mite, and carmine mite were not afcted at all by either the previous or simulneous applications of inhibitors. 5) The properties of the fluoroacetanilidase in Mealy plum aphid seemed to be considerably different from those in worm-blooded animals. Especially, the former was not inhibited by TPP even at the concentration of 10-4M.