Abstract
The effect of a small protective dose of carbon tetrachloride (CCl 4) on hepatic microsomal lipid peroxidation induced by a larger dose of CCl 4 24 h later was investigated. Endogenous hepatic microsomal lipid peroxidation as well as CCl 4-stimulated lipid peroxidation were decreased by treatment of rats with a small protective dose of CCl 4. Furthermore, glutathione peroxidase and glutathione reductase activities were not altered by single or repeated administration of CCl 4. The results suggest that destruction of cytochrome P-450 by the protective dose of CCl 4 prevents bioactivation of a subsequent dose of the hepatotoxin and, therefore, protects against lipid peroxidation and cell damage.
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