Abstract
It appears that vitamin B12 is not directly involved in transmethylation in the animal body nor in the biosynthesis of liver ribose or desoxyribose nucleic acids. On the other hand, vitamin B12 is definitely required for methyl group synthesis from various one-carbon precursors including serine, glycine, formate, and formaldehyde, and its role in one-carbon metabolism appears to influence the incorporation of certain one-carbon compounds into the uric acid excreted by the chick. Preliminary evidence indicates the involvement of vitamin B12 in protein synthesis.
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