Studies on the mechanism of action of aminooxyacetic acid: II. Possible pyridoxine deficiency as a mechanism of action of aminooxyacetic acid toxicity

Abstract

Summary A vitamin B 6 deficiency in rats was produced by chronic administration of aminooxyacetic acid. Increased urinary excretion of xanthurenic acid was used as an index for vitamin B 6 deficiency. Xanthurenuria induced by administration of aminooxyacetic acid was associated with ultimate death of the animals. Animals removed from aminooxyacetic treatment before death ensued recovered from their xanthurenuria. Concomitant administration of pyridoxine and aminooxyacetic acid resulted in increased toxicity but no xanthurenuria.