Abstract
Abstract Two new cytotoxic macrolides, amphidinolides R (1) and S (2), were isolated from the cultured marine dinoflagellate Amphidinium sp. and their structures including absolute configuration were elucidated on the basis of spectroscopic data as well as chemical experiments. In a feeding experiment of 13C-labeled succinic acid into a culture of Amphidinium sp., no enrichment of the 13C NMR signal intensity of any carbon of amphidinolide J (3), the most abundant macrolide in this dinoflagellate, was observed.
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