Abstract
SUMMARY Several reports of an increased incidence of malignant disease in renal homograft patients, who were under immunosuppression, led us to consider the possibility of chromosome damage to the lymphocytes in such patients. Peripheral blood samples from 19 renal homograft recipients and 19 patients being treated by haemodialysis were studied. Chromosome damage in excess of normal levels was observed in the lymphocytes of both groups. The damage in the homograft patients could be attributed almost exclusively to radiation therapy. There was no evidence of increased chromosome damage in immunosuppressed patients who had not been irradiated. No obvious explanation could be found for the elevated levels of chromosome damage in the dialysis patients. The response of the lymphocytes to phytohaemagglutinin (PHA) was depressed in the homograft patients.
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