Abstract

The variation among individual animals in the degree of susceptibility to applications of a single carcinogenic agent has led us to make an analysis of the internal organs in an endeavour to ascertain, if possible, whether there was any dissimilarity in the morphology of the organs, etc., which might account for a difference in animal susceptibility. The relation, if any, of state of general health to tumour development was one of the main issues involved. We have already published some of our preliminary observations on the liver, spleen, thyroid, and other organs,1 but during the last two years we have widened our field considerably, and have examined a much greater number of animals, although our numbers are still in many instances too small for reliable conclusions to be drawn from the observations made. In the present paper our discussion will centre chiefly around the body weight of the animal in relation to special features found in certain of the organs only. The organs with which we shall deal are the skin, liver, spleen, thyroid, parathyroids, brain, and pituitary gland. The special features relating to the organs with which we are at the moment concerned are:

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