Studies on the intermediary metabolism of carbohydrate in diabetic patients

Abstract

In an attempt to study the intermediary metabolism of carbohydrate in diabetic patients, the authors measured the blood glucose, pyruvic acid, lactic acid and inorganic phosphate following the administration of glucose (22 cases intravenously and 19 cases orally), and the following results were obtained ; 1. From the results of blood glucose and inorganic phosphate following the administration of glucose, the process of phosphorylation in the blood is almost inhibited in diabetic patients compared to the healthy persons and a marked depression of this process were found in severe cases of diabetics. Following the administration of glucose, the significant high blood lactic acid levels of severe cases of diabetic patients were lowered; acommpanying with rised pyruvic acid in the blood, while in the mild and moderate diabetic patients the increased blood lactic acid with no change of blood pyruvate were seen. It is clear from these results that a definite different response to intermediary carbohydrate metabolism following the administration of glucose may have been occured in the severe diabetic patients compared with those of mild diabetic patients or healthy persons.