Studies on the interaction between α-amino acids with polar side-chains and heterocyclic compounds at T=298.15 K

Abstract

Mixing enthalpies of aqueous l-serine and l-threonine solutions and aqueous tetrohydrofuran (THF) and 1,4-dioxane solutions and their dilution enthalpies have been determined with a Thermometric-2277 Thermal Activity Monitor at T=298.15 K. The h xy values, obtained with the McMillan–Mayer formalism, for the α-amino acids bearing polar side-chain ( l-serine and l-threonine) with THF and 1,4-dioxane are compared with values reported in the literature for the α-amino acids with non-polar side-group (glycine, l-alanine, l-aminobutyric acid and l-valine) with THF and 1,4-dioxane. The results are interpreted in terms of solute–solute interactions. The group additivity concept by Savage and Wood (SWAG) has also been used. Contributions of each amino acid, functional group have been estimated.