Abstract
The Maillard-derived chromophore 3-hydroxy-4-[(E)-(2-furyl)methylidene]methyl-3-cyclopentene-1,2-dione (1) was found to potently inhibit the growth of human tumor cells in vitro. In growth inhibitory concentrations, 1 shuts down the activity of the mitogen-activated protein kinase cascade, measured as inhibition of the Elk-1 phosphorylation. At concentrations ≥30 μM, the chromophore significantly reduced the integrity of the microtubule skeleton.
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