Year-end Sale % OFF 
Abstract
This chapter discusses studies on the influence of T cells in antibody production. Evidence is now available for the involvement of at least two lymphoid cell types in antibody responses to some heterologous erythrocytes and serum proteins. Studies on immunological tolerance and carrier–hapten relationships strongly suggest that antigenic reactivity is a property of both cell types. Antibody secretion has been demonstrated only in cells derived directly or after a period of maturation (in a site other than the thymus), from cells in the bone marrow. The site of origin of these cells (B cells) is presumably homologous to the bursa of Fabricius in chickens. Thymus-influenced cells (T cells, thymus-dependent cells, thymus-derived cells) facilitate total antibody production in the B-cell lineage. The chapter presents studies focusing on theta alloantigen as a marker for T cells. Further, the influence of treatment with anti-theta on the in vitro response of spleen cells from neonatally thymectomized mice to SRBC was also discussed. Influence of thymectomy on IgM and IgG antibody production to SRBC and the synthetic polypeptide (T, G)-A-L was also described.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
