Abstract
Liver serine dehydratase differs in its response to the administration of cortisone and l-tryptophan in intact and adrenalectomized rats. While the enzyme synthesis de novo is increased by the administration of tryptophan or cortisone in intact rats, cortisone but not tryptophan stimulates synthesis of the enzyme in adrenalectomized animals. The magnitude of the enzyme's increase after tryptophan administration depends on the protein content of the diet and the length of starvation of the animals prior to the induction. While the combination of cortisone with tryptophan does not result in a further enhancement of hepatic serine dehydratase in rats with intact adrenal glands, glucagonmediated induction of the enzyme in these animals can be further increased by giving the amino acid. No such effect was found in adrenalectomized animals. Both the increase of serine dehydratase activity caused by tryptophan in intact, and by cortisone in adrenalectomized rats is associated with the appearance of form I of serine dehydratase as well as an increase in the total activity of the enzyme.
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