Abstract
The study was carried out to evaluate the hypolipidemic and hypoglycemic effect of Nelumbo nucifera leaf powder. In rats, hyperlipidemia was induced by feeding High Fat Diet (Lab diet: Dalda: Coconut oil = 4:3:1) and type 2 diabetes was built inside by injecting Alloxan. The sample N. nucifera leaf powder was added in different percentages with the regular Lab Diet for 21 days feeding. In case of hyperlipidemia developed groups, feeding of Nelumbo nucifera leaf powder at, 30% (70% Lab diet + 30% Sample), 20% (80% Lab diet + 20% Sample) and 10% (90% Lab diet + 10% Sample) showed varied but in a nutshell significant (p Nelumbo nucifera leaf powder for 21 days resulted significant decrease in the blood glucose levels of alloxan-induced diabetic rats. Both the percentages of Nelumbo nucifera leaf powder having 20% with 80% Lab Diet and 10% with 90% Lab Diet significantly (p Nelumbo nucifera powder was found to be exerted to the more prominent effects in lowering the blood glucose level. Nelumbo nucifera leaf powder had 75% efficacy rate in lowering the blood glucose level in comparison to the drug control group treated with glibenclamide which was found with the decreasing capability up to 66%. Although not significant, it, based on the data, can be stated that the sample is endowed with the quality of decreasing capability of body weight. Thus, results of the experimental study reveal that the leaf of Nelumbo nucifera has potent hypoglycemic and hypolipidemic properties.
Highlights
Lipid disorders are usually associated with diabetes which in turn acts as one of the prime causative factors for cardiovascular morbidity and mortality in patients suffering from diabetes [1]
Nelumbo nucifera leaf powder had 75% efficacy rate in lowering the blood glucose level in comparison to the drug control group treated with glibenclamide which was found with the decreasing capability up
According to the current conducted epidemiological study in Bangladesh, more than 11% diabetic population are attacked by type II diabetes and the prevalence of impaired fasting glucose, which triggers the inception of diabetes, exceeds 6% in Dhaka city [6]
Summary
Lipid disorders are usually associated with diabetes which in turn acts as one of the prime causative factors for cardiovascular morbidity and mortality in patients suffering from diabetes [1]. Among all the endocrine disorders, diabetes mellitus is the most prevalent one and almost three hundred million will suffer from the disease by 2025 [3] and major portion of diabetic population will be from India, China and United States [4] [5]. According to the current conducted epidemiological study in Bangladesh, more than 11% diabetic population are attacked by type II diabetes and the prevalence of impaired fasting glucose, which triggers the inception of diabetes, exceeds 6% in Dhaka city [6]. In the studies of hypoglycemic effects, the subjected animals are being made diabetic using alloxan, streptozotocin (STZ) etc introducing inside injecting intraperitoneally (IP) or intravenously (IV). Ethnopharmacological studies reveal that more 1200 plants are utilized in traditional medicine for their alleged hypoglycemic activity [11]
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