Abstract
Nowadays, smokeless tobacco consumption in the form of gutkha is receiving more popularity among the youth of India. In the present investigation, cytogenetic studies were carried out on 50 gutkha consumers and compared with controls, 50 men who did not have habit of smoking, alcohol drinking and consuming gutkha, tobacco and areca nut in any form. Frequency of chromosome aberrations (CA) and sister chromatid exchanges (SCE) were evaluated in peripheral blood lymphocytes, whereas frequency of micronucleated cells (MNC) was evaluated in exfoliated buccal mucosa. A significant increase (p 31) compared with low age group individuals viz CA (1.67-2.81), SCE (4.65-5.80), MNC (0.36-0.70). The increased frequency of these end points was found to be significantly correlated ( p<.001) with duration of consumption (b = 0.193, 0.039, 0.032 for CA, SCE and MNC respectively) and number of pouches consumed per day (b being 0.193, 0.441, 0.429 for CA, SCE and MNC respectively). Besides this, significant dif ference was found between the mean values of CA and SCE among gutkha consumers and gutkha consumers + drinkers + smokers and also significant increase was found between gutkha consumers + smokers and gutkha consumers + drinkers + smokers for CA.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
