Abstract
Sendai virus which had been cloned by successive plaque purification was found to generate a wide assortment of defective-interfering (DI) genomes on continued high-m.o.i. passage in eggs. No predisposition to generate a particular DI genome was noted. One stock of Sendai virus, which contained 13 different DI genomes varying in length from 670 to 7100 nucleotides was passaged undiluted in eggs for several more generations to see whether the smaller DI genomes could be selectively amplified. Our results indicate that the size of the DI genome per se does not confer a selective advantage and the implications of this finding are discussed.
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