Abstract
Gastric secretory effect and other pharmacological effect of tetragastrin, a synthetic gastrin-like substance, were examined. Tetragastrin did not show any severe acute toxicity in mice and rabbits, but showed respiratory stimulation, retching, and vomiting in dogs. The gastric secretion in Heidenhain pouch dogs was increased by the subcutaneous administration of tetragastrin and also increased in Schild rats by its subcutanous or intravenous administration. In chloralose anesthetized dogs, tetragastrin produced an increase in volume flow of bile and pancreatic juice, and stimulated the motility of stomach or pyloric sphincter.
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Schedule a callMore From: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
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