STUDIES ON THE EXCRETION MECHANISM OF SEROTONIN (5-HYDROXYTRYPTAMINE) IN THE CHICKEN KIDNEY.

Abstract

AbstractSanner, E. Studies on the excretion mechanism of serotonin (5‐hydroxytryptamine) in the chicken kidney. Acta physiol. stand. 1963. 58. 330—341. — Serotonin at a dose of 150—200 μg was injected into the leg vein of the chicken together with phenol red and tolazoline. All birds were pre‐treated with a MAO inhibitor (JB‐516, Catron®). The tubular excretion of serotonin was inhibited by simultaneous administration of tolazoline at a dose of 5—15 mg into the leg vein. Probenecid at a dose of 50 mg/kg given into the wing vein 1 hour prior to serotonin — phenol red injections gave a strong inhibition of phenol red excretion but left the serotonin excretion unchanged. Brom cresol green at a dose of 1 mg caused a specific inhibition of phenol red transport but left serotonin transport unchanged. Cyanine dye # 863 at a dose of 2 mg did inhibit the serotonin transport but such a big dose also interfered with phenol red transport capacity. Smaller doses of cyanine dye gave a weak inhibition of serotonin transport and did not alter the phenol red transport to any great extent. Reserpine did not inhibit either serotonin or phenol red transport. pH of the chicken urine did not influence the excretion of serotonin.