Abstract
The establishment of immune tolerance after feeding a single large dose of picryl chloride to previously starved guinea pigs requires a minimal induction period of approximately 48 to 72 hours. Resistance to anaphylactic sensitization is regularly present at two days and reaches the highest levels by four days. In contrast, contact tolerance occurs sporadically at 72 hours and gradually increases in frequency to reach the maximum rate of inhibition over an interval of 18 to 21 days.
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