Abstract
oxygen consumption isreconstituted (7). Intheabsence ofoxygen, all cytochromes inthis reconstituted system arerapidly reduced bypyruvate viatheenzyme. However, reconstitution and cytochrome reduction cannot beachieved withproteolytically activated pyruvate oxidase, eventhough this form oftheenzymerapidly reduces soluble electron acceptors suchasferricyanide. Apparently thesamestructural features oftheenzymethatpromote itsinteraction with lipids areimportant inits interaction withthemembraneboundelectron transport chain. Thestudy oftheprotein-lipid interactions ofpyruvate oxidase hasbeenparticularly fruitful. Consideration ofthe reciprocal effects between thecatalytic ligands andlipid activators leads tothekeypoint that protein-lipid interactions canbeallosterically controlled inamanner similar to thatalready welldocumented forinteractions between proteins andmetabolites andforprotein-protein interactions.
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