Abstract

The susceptibility of male ICR-strain mice to infection with Mesocestoides corti tetrathyridia, together with the effects of administering both orally and intraperitoneally free and liposomised albendazole to mice over different periods of infection, have been studied. An enhanced rate of asexual multiplication of the parasite was observed both in the liver and, more so, in the peritoneal cavity, reflecting a high susceptibility of this strain of mice to infection. The efficacy of free ABZ and liposomised ABZ against M. corti tetrathyridia was greater when administered in 10 doses over days 14–23 post-infection (p.i.) than over days 23–32 p.i.; and six doses of the drug given over days 14–19 p.i. were more effective than three doses over days 14–16 p.i. The efficacy of three doses of liposomised ABZ administered intraperitoneally, and comprising half the concentration of free ABZ administered orally, was approximately the same as that for free ABZ; and six doses of either formulation administered from day 14 p.i. were slightly more efficacious in the liver.

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