Abstract
Addition of distamycin A to a DNA dependent RNA polymerase system blocks instantaneously the initiation of new RNA chains. Under the conditions used, elongation of growing chains is resistant to the action of the drug up to 4 minutes after addition of the antibiotic. Studies using density gradient centrifugation to follow the formation of the enzyme-DNA complex reveal that distamycin A inhibits the binding of the polymerase to DNA.
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