Abstract
ABSTRACT The effects of cortisol and ACTH in vivo on various mouse lymphatic tissues were studied, using the current techniques for isolation of adenine from nucleic acids and quantitative measurement, including chromatography, spectrophotometry and radioactive tracer methods. The incorporation of adenine-8-14C into both RNA and DNA of lymphatic tissues of intact mice was reduced following prolonged treatment with cortisol or ACTH. In the absence of the adrenals ACTH enhanced the incorporation of adenine-8-14C into the RNA of lymph nodes, spleen and thymus, although a clearcut effect on increased incorporation of the purine into DNA was limited to the spleen. It was concluded that ACTH has an extraadrenal effect on lymphatic tissues.
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