Studies on the dynamics of the cerebrospinal fluid using radioactive isotopes. I. The formation and the absorption of cerebrospinal fluid.

Abstract

Upon studying the relation between the production of CSF and the intracranial pressure in patients with various surgical brain diseases and the effect of intravenous injection of 50% glucose solution on the production, by following up the turnover of P-32 from blood to CSF, it was confirmed that CSF production was of course inactive in the cases without increased intracranial pressure, but in the cases with increased intracranial pressure too, the production was not always correlated with the rise of the intracranial pressure. The production was particularly active in the highpressure cases with advanced destruction of the blood-CSF barrier, as in the malignant glioma cases, but relatively inactive in the cases with equally high intracranial pressure due to obstruction of the aqueduct of Sylvius but apparently mild destruction of the blood-CSF barrier. Upon injection of 50% glucose solution, the production of CSF was inhibited to some extent in all cases, the inhibition being particularly notable in the cases with drastic destruction of the blood-CSF barrier.