Abstract
A 14C-labelled chlorinated paraffin (CP) preparation ([1- 14C]-polychlorohexadecane, 34·1% chlorine by weight) was given to C57 B1 mice. The distribution was studied with whole body autoradiography and the radioactivity in selected tissues, and in expired air and excreta, was measured. As a comparison, the distribution and metabolic degradation of [1- 14C]-palmitic acid were also investigated. The distribution pattern of the CP preparation was characterised by a marked uptake of radioactivity in tissues with high cell turnover rate and/or high metabolic capacity, e.g. in the brown fat, intestinal mucosa, bone marrow and exocrine glands. The exhalation study showed that 44% and 33% of the administered radioactive dose was eliminated as [ 14C]-carbon dioxide within 12h after intravenous and peroral administration, respectively. Thin layer chromatography further indicated that the absorption of the intact molecule from the gastro-intestinal tract was significant. The palmitic acid gave a similar distribution pattern but a more pronounced exhalation of [ 14C]-carbon dioxide (65%). It is concluded that the CP preparation is, at least partly, degraded via intermediary metabolic routes for endogenous substances, but other metabolic pathways and routes of excretion probably also occur.
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