Studies on the cytopathic effects of Newcastle disease virus: RNA synthesis in infected cells.

Abstract

Many viruses, in addition to the induction of c.p.e., produce profound biochemical alterations in the cell, particularly by the inhibition of cellular macromolecular synthesis (for review see Roizman & Spear, 1969). Reeve et al. (1971) have shown that the ability of different Newcastle disease virus (NDV) strains to inhibit cellular protein synthesis is related directly to their virulence for cells in vitro and for eggs and chickens in vivo. Certain NDV strains can also inhibit cellular RNA synthesis, but the relationship of this property to the virulence of the infecting strain is not clear (Wheelock & Tamm, 1961; choltissek & Rott, 1965; Wilson, 1968). Moore, Lomniczi & Burke (1972) examined 13 strains of NDV but were unable to establish a relationship between virulence and the inhibition of host cell RNA synthesis.