Abstract
ACCORDING to available evidence the urinary 17-ketosteroids are derived solely from steroids of the adrenal cortex and testes. It has been assumed that changes in the amounts of the 17-ketosteroids in urine reflect alterations in function of these glands. However, this view oversimplifies the picture and interpretations of data on urinary 17-ketosteroids must remain uncertain so long as the factors which influence the metabolism of their precursors remain largely unknown. Although many different 17-ketosteroids (1) have been isolated from normal and abnormal urines, it appears that the 17-ketosteroids found in largest amounts in normal human male and female urines under usual circumstances of analysis are androsterone and etiocholan -3(α)-o1-17- one. That they are derived from the adrenal cortex is clear but it is unknown whether the adrenal cortical precursors are, in the main, androgenic, 19-carbon steroids (possibly, Δ4-androstene-3, 17-dione or even dehydroisoandrosterone) or native 21-carbon pregnene...
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