Studies on the constituents of Luffa operculata Cogn. I. Isolation and structures of luperosides A-H, dammarane-type triterpene glycosides in the herb.

Abstract

Eight dammarane-type triterpene glycosides named luperosides A-H were isolated from the dried herb of Luffa operculata COGN. (Cucurbitaceae). Their structures were determined on the basis of chemical and spectral evidence as follows. A : a 3, 20-bis-O-β-D-glucopyranoside of (20S)-dammar-24-ene-3β, 7β, 20-triol (Ag). B : a 20-O-β-gentiobioside of Ag. C : a 3-O-β-neohesperidoside-20-O-β-D-glucopyranoside of Ag. D : a 3-O-β-D-glucopyranoside-20-O-β-gentiobioside of Ag. E : a 3-O-β-neohesperidoside-20-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside of Ag. F : a 3-O-β-neohesperidoside-20-O-β-gentiobioside of Ag. G : a 3-O-β-neohesperidoside-20-O-β-gentiobioside of (20S)-dammar-23-ene-3β, 7β, 20, 25-tetraol. H : 3-O-β-neohesperidoside-20-O-β-gentiobiosides of (20S, 24S and R)-dammar-25-ene-3β, 7β, 20, 24-tetraols.