Studies on the Constituents of Cucurbitaceous Plants

Abstract

I have an opportunity to have co-operative studies with Chinese group of Kunming Institute of Botany. Since then, I have investigated the chemical constituents of a number of Chinese plants of Araliaceae, Umbelliferae, Labiatae, Cucurbitaceae and other families. This review describes the structural elucidation of the cucurbitane, oleanane and dammarane glycosides, and their biological activities under the joint studies on cucurbitaceous plants, Bolbostemma, Hemsleya, Siraitia and Neoalsomitra species. New oleanane glycosides having novel cyclic structure were isolated from Bolbostemma paniculatum. The potent solubilizing effect of these compounds was investigated. A number of cucurbitane glycosides were isolated from Hemsleya carnosiflora, H. panacis-scandens, Siraitia grosvenorii and S. siamensis. Some of these glycosides taste sweet, bitter or tasteless. The structure-taste relationships of the glycosides of a 3-alpha-hydroxy-cucurbit-5-ene-type triterpene have been discussed. Anti-tumor-promotion effects as well as the ecdysteroid agonist and antagonist activities of these cucurbitane glycosides were investigated. New dammarane glycosides were isolated from Neoalsomitra integrifoliola.