Abstract
The conformations of O-uridine-5′-yl O-alkyl N-phosphoryl serine methyl esters (1) and (2) have been investigated by nuclear magnetic resonance (NMR) and circular dichroism (CD) techniques, Nuclear Overhauser effect (NOE) measurements and CD studies revealed that the glycosyl bonds in both compounds favor the syn orientation. The stereosensitive 31P-13C coupling constants were also measured and used for the analysis of the trans and gauche conformations. The three-dimensional structural characteristics of compounds (1) and (2) were discussed.
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