Abstract
A sulpho-mucopolysaccharide fraction has been prepared from the palatine processes of 14-day-old mouse embryos, whose mothers had been given radioactive sulphate on the 12th day of pregnancy. Analysis of the fraction showed uronic acid and hexosamine in equimolar amounts. On paper eleclrophoresis, the substance isolated, which could be localized by meta-chromasia and 35S activity, was found to migrate in the same way as chondroitin sulphuric acid A. It is concluded that the sulpho-mucopolysaccharide fraction isolated contains one or more chondroitin sulphuric acids. The possible role of the mucopolysaccharides in closure of the secondary palate is discussed.
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