Studies on the chemical constituents of rutaceous plants. LVI. The development of a versatile method for the synthesis of antitumor-active benzo(c)phenanthridine alkaloids. 6. Limitation of the Dyke synthetic pathway for benzo(c)phenanthridine alkaloids.

Abstract

A limitation of the Dyke method for synthesizing benzo [c] phenanthridine alkaloids through the 1, 2-dihydroisoquinoline derivatives prepared by means of the Pomeranz-Fritsch reaction was clarified ; the method is not applicable to such alkaloids having an alkoxy group at the C10 position.