STUDIES ON THE BLOOD COAGULATION IN THE FIELD OF OBSTETRICS AND GYNECOLOGY

Abstract

Blood coagulation factors of patients with functional uterine bleeding, uterine cancer, sterility, and of pregnant and puerperal women and oral contraceptive users were compared with those of controls having the normal menstrual cycle. Further, using sera from the above mentioned patients, comparative study was made on stasis thrombus.The results obtained were as follows : 1. Blood coagulation factors of the patients with functional uterine bleeding were not significantly different from those of the controls.2. The patients with uterine cancer did not show any difference in the factors except significant increase in fibrinogen.3. The sterile patients had no significant difference from the controls.4. Factor VII activity was significantly increased in the first trimester of pregnancy and then gradually increased with the advance of the month. Amount of fibrinogen was significantly augmented from the eight month of pregnancy.5. In the puerperal women, both factor VII activity and fibrinogen were significantly increased within one week after delivery, and still remained so after one month. But prothrombin time did not show any change.6. In the oral contraceptive users, factor VII activity and fibrinogen were significantly increased independent of duration of drug administration. No change was observed in prothrombin time.7. Comparison between thrombus formation rates in sera from the pregnant and puerperal women and oral contraceptive users revealed that the rates in the first trimester were as low as those of healthy non-pregnant women, however, high after 20 weeks of pregnancy, in the puerperium and during usage of oral contraceptive drug.8. Significant correlation was observed between period of pregnancy and factor VII activity.9. From the above mentioned results, it was known that blood coagulation factors were activated nearly to the same degree in pregnant and puerperal women and oral contraceptive users, and that thrombus formation rates in sera from them were higher than in healthy non-pregnant women.There was, however, no correlation between thrombus formation and activation of blood coagulation factors.It is, therefore, assumed that not the activation of fibrinogen and factor VII but that of factors XI, XI and XII will have direct bearing on thrombus formation.