Abstract
An extract obtained from pig livers after perfusion with C 14-carboxyl-labeled sodium acetate, alkaline hydrolysis, and extraction with pentane was separated into four main fractions by chromatography on alumina. The pentane eluates contained squalene-C 14 which after intraperitoneal injection or feeding to rats was converted into cholesterol-C 14. Two other fractions from the chromatogram also gave cholesterol-C 14 on intraperitoneal injection or feeding in rats. Squalene was also for the first time isolated from a mammalian (pig) liver. It is concluded that besides squalene a number of intermediates of the conversion of acetate into cholesterol are present in the nonsaponifiable matter of perfused livers and possibly also of normal livers.
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