Abstract
Molecular distribution profiles for FSH in anterior pituitary extracts or serum of infantile female rats (10–12 days of age), as determined by exclusion chromatography, were compared to those of prepubertal (27 days) or adult (70 days) rats. The elution position of pituitary FSH at the different ages studied was essentially the same, indicating the absence of major differences in average apparent molecular size. Characterization of serum FSH revealed a preponderance of FSH components of larger molecular size. However, the elution position of serum FSH was similar at all ages studied. Small quantitative differences were found between pituitary FSH potencies assessed by RIA or by bioassay. However, at the two ages studied (12 and 27 days) the immunoassay/bioassay ratios were similar. Pituitary FSH of both infantile and older female rats showed a dose-response curve in the ovarian hCGaugmentation assay parallel to that of NIH-FSH-S11. Ovaries from 29 day old rats transplanted to other prepubertal animals (23...
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