Abstract
ABSTRACT Seven assays were carried out for sheep luteinizing hormone (LH) by the method of simultaneous response of the ovary and uterus in the intact immature rat. The parameters of these assays were then compared with similar constants derived from assays for human pituitary gonadotropin (HPG) of urine. The shapes of the dose-response curves for LH were greatly different from those for HPG. The response to LH is biphasic, consisting of a small increment in growth of both ovary and uterus, followed by a plateau, after which another increment in ovarian and uterine growth occurs. The response to HPG of both ovary and uterus is a linear function of the log of the dose. LH also is loss effective than HPG in inducing estrogenic secretion in this assay system. It was concluded that HPG, although it possesses the biologic properties of LH in addition to its follicle-stimulating properties, is totally dissimilar to purified LH in this assay system.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Journal of clinical endocrinology and metabolism
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
