Abstract
Summary and Conclusions Sera from guinea pigs and rabbits of normal stock contain relatively thermostable antibodies which mediate the killing of apparently S-state cells of Salmonella typhosa by complement. The “normal” bactericidins appear to be specific for antigenic factors IX and XII, which are characteristic for the surface of S-state S. typhosa cells. An additional factor, present in all normal sera tested, depresses the bactericidal activity against S. typhosa O 901 cells and also interferes with the adsorption of the antibodies responsible for sensitization of S. typhosa O 901 cells to cells of antigenically related, apparently S-state, Salmonella species. It has been suggested that the inhibiting factor may be an antibody specific for an antigen which is prominent in determining the antigenic characteristics of the surface of R-state cells, but is also present, though less prominently, on the surface of apparently S-state Salmonella cells.
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