Abstract
Judkin et al. have shown that the mortality from atherosclerotic heart disease was more closely related to sugar consumption than fat consumption. Some people claim that Judkin’s data are not supported by experimental evidence. It has been reported by our group and Dalderup et al. that high sucrose feeding can induce vascular lesions in aorta, heart, and kidney in rabbits, rats, and beagle dogs. We reported precise pathologic findings of sucrose-induced vascular lesions in those animals. The purpose of the present study was to investigate the vascular lesions and metabolic changes in male crab-eating monkeys fed a high-sucrose diet for 42 months. Since the crab-eating monkey is more closely related to human phylogenetically, it is reasonable to postulate some aspects of human atherosclerosis by investigating the correlation between metabolic changes and pathologic findings observed in monkeys fed a high-sucrose diet.
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