Abstract
This review aimed to assess the antioxidant properties of safrole, myristicin, and terpineol from Myristica fragrans Houtt. Safrole exhibited high antioxidant and cytotoxic activities against numerous cancer cell lines and also shown able to suppress tumor cell angiogenesis. Myristicin is able to increase the activity of glutathione peroxidase (GPX), glutathione reductase (GR) or glutathione-disulfide-reductase (GSR), superoxide dismutase (SOD), and catalase (CAT). Myristicin is also able to reduce the level of lipid peroxidation (LP) or lipid degradation. Terpineol or also known as alpha terpineol (α-T) revealed high antioxidant and cytostatic activities against several human cancer cell lines, especially breast adenocarcinoma (MCF-7) and myeloid leukemia (K-562).
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