Abstract
The methanol:dichloromethane extract of Combretum calobotrys Engl & Diels (Combretaceae) leaves (CCE) was subjected to solvent-guided fractionation to yield the hexane (HF), dichloromethane (DF) and methanol (MF) fractions. The anti-inflammatory effects of the extract and fractions were evaluated in rodents using xylene-induced topical ear edema, carrageenan-induced pedal edema, formaldehyde-induced arthritis and cotton pellet granuloma tests, respectively. The extract and fractions were screened for analgesic activity using acetic acid induced writhing and formalin test in rodents. They were subjected to antimicrobial assay and also analysed for phytochemical constituents, while the CCE was subjected to acute toxicity (Lethal dosage, LD50) test using standard procedures. The extract and fractions (200 and 400 mg/kg) significantly (P 5,000 mg/kg. The results indicate that C. calobotrys leaf possess anti-inflammatory, analgesic and antimicrobial activities. Key words: Combretum calobotrys, anti-inflammatory, analgesic, abdominal writhing, formalin test, agar dilution.
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