Abstract
The anticonvulsant activity of carbon dioxide has been found to be antagonized by reserpine. Alpha adrenergic blocking agents and the alpha methyl analogs of tyrosine antagonize the anticonvulsant action or acetazolamide but not that of carbon dioxide. The results suggest that these pharmacologic agents may antagonize acetazolamide by altering its absorption of distribution. It is also possible that the increased levels of CO 2 produced by acetazolamide may differ in some way from those produced by the inhalation of CO 2 .
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