Abstract
Antibacterial action of human saliva has been reported by numerous investigators. Among the antibacterial factors in human saliva, lysozyme, inhibine, and anti-lactobacillus factor are the most familiar and with the most extensive studies. Recently, the nature of the antilactobacillus factor which required thiocyanate for its activity has extensively clarified to be a salivary peroxidase. The salivary peroxidase antibacterial system consists of three components, peroxidase, hydrogen peroxide and thiocyanate.Concerning the salivary antibacterial factor and its relation to dental caries, Hill found an anti-lactobacillus casei factor to be present in the whole saliva of caries resistant individuals. Green, Dodd and Inverso also reported a non-dialyzable, heat labile factor in the saliva of caries immune individuals which inhibited the growth of lactobacilli and streptococci. This substance was found lacking in the saliva of caries susceptible individuals. Matsumura, Morioka and Onishi reported an inverse proportion between the activity of salivary antibacterial factor (S.A. Factor) and DMF teeth rate. No experimental work, however, exists describing the salivary antibacterial factor (s) against cariogenic lactobacilli.The purpose of this experiment is to determine the antibacterial and bactericidal action of the salivary peroxidase antibacterial system on cariogenic Lactobacillus casei ATCC 4646 (Rosen, Lenney and O'Malley, 1968).As the results, growth of cariogenic Lactobacillus casei was apparently inhibited in SL broth (pH5.4) by the human salivary peroxidase antibacterial system. This antibacterial activity was quantitatively determined in the culture medium. The cariogenic lactobacillus was markedly killed by the antibacterial system in human saliva at pH5.8.This experiment is important in that it helps to clarify the physiological significance of the salivary peroxidase antibacterial system in oral cavity with the direct evidence of the bactericidal action on the cariogenic lactobacillus.
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