Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex.

Munkhtugs Davaatseren,Yeon-Ji Jo,Haeng Hur,Mi-Jung Choi,Geun-Pyo Hong,Sujin Park

doi:10.3390/molecules22121868

Abstract

trans-Cinnamaldehyde (tCIN), an active compound found in cinnamon, is well known for its antioxidant, anticancer, and anti-inflammatory activities. The β-cyclodextrin (β-CD) oligomer has been used for a variety of applications in nanotechnology, including pharmaceutical and cosmetic applications. Here, we aimed to evaluate the anti-inflammatory and antioxidant effects of tCIN self-included in β-CD complexes (CIs) in lipopolysaccharide (LPS)-treated murine RAW 264.7 macrophages. RAW 264.7 macrophages were treated with increasing concentrations of β-CD, tCIN, or CIs for different times. β-CD alone did not affect the production of nitric oxide (NO) or reactive oxygen species (ROS). However, both tCIN and CI significantly reduced NO and ROS production. Thus, CIs may have strong anti-inflammatory and antioxidant effects, similar to those of tCIN when used alone.

Highlights

Cinnamon is commonly used in cosmetics and foods [1], and cinnamon oil is frequently used in the food and beverage industry because of its unique aroma [2]
We evaluated the effects of CIs on nitric oxide (NO) production in LPS-induced RAW264.7 macrophages
TCIN was solubilized by formulating it as an inclusion complex with β-CD polymer using molecular inclusion techniques

Summary

Introduction

Cinnamon is commonly used in cosmetics and foods [1], and cinnamon oil is frequently used in the food and beverage industry because of its unique aroma [2]. Several studies have reported that cinnamon and its extracts and active compounds have beneficial biological effects, including antidiabetic effects [1,3], and antibacterial, antifungal, and anticancer activities [2,4]. These products inhibit neuroinflammation [5] and reduce oxidative stress [6,7]. The compound trans-cinnamaldehyde (tCIN) is a key flavor component of cinnamon essential oil [8] that has relatively low toxicity, aside from inducing skin irritation at high doses [9]. The oral absorption of high amounts of cinnamon into the human body

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