Abstract
The acute toxicity of the recently discovered antiproliferative and antineoplastic agent trans-bis- (salicylaldoximato)copper(II) (CuSAO 2) has been studied in Wistar rats. When given perorally as a suspension, the compound had no acute lethal toxicity even at the dose of 5000 mg per kg body weight. The peroral LD 50 value (in rats) of the corresponding free ligand, salicylaldoxime, is known to be only 400 mg/kg. The decreased toxicity of CuSAO 2, as compared to the free ligand, may at least in part be due to its lack of absorption. CuSAO 2 was found to be absorbed poorly, if at all, when given perorally. When CuSAO 2 was given intraperitoneally to Wistar rats, its absorption was found to be incomplete, and therefore no attempt was made to determine its intraperitoneal LD 50 value.
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