Abstract

1. 1. d-Galactose was found to inhibit the o-aminophenyl glucuronide synthesis in the rat liver and kidney slices, but no effect was obterved in the slices of jejunum. 2. 2. d-Galactosamine inhibited the glucuronide synthesis only in the liver. 3. 3. The sensitivity of glucuronide synthesis in the liver depends on the rapid activation of d-galactose and d-galactosamine to UDP compounds. 4. 4. UDP-Glucuronic acid and, to a lesser degree, UDP-glucose reversed the inhibition caused by d-galactose and d-galactosamine in the liver slices.

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